Histologic examination of prostate tissue. Surgical pathology level 4 (per individually identified specimen site), with microscopic interpretation and report.

PTEN (10q23.32) and TMPRss2-ERG (21q22.2) loci are assessed by fluorescent in situ hybridization (FISH) using three-color MetaSystems XCyting locus-specific probes. Aberrations of ERG (deletion, copy number increase, and rearrangement) have been reported in prostate cancer. Deletions of PTEN have been reported in prostate cancer.