Cytogenetic abnormalities commonly associated with B-cell non-Hodgkin lymphomas (NHL) are detected by fluorescence in situ hybridization (FISH). Probes for BCL6 (3q27.3), 6q (6q-/-6), MYC (8q24.21), IGH/CCND1 t(11;14), IGH/BCL2 t(14;18) and MALT1 (18q21) are included in the B-NHL FISH Profile.
disease state indication(s)
B-cell non-Hodgkin lymphomas (NHL), follicular lymphoma (FL), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma (LPL), diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), and double-hit lymphoma (DHL)
The B-NHL FISH Profile detects cytogenetic abnormalities commonly associated with various subtypes of B-cell non-Hodgkin lymphomas (NHL).
Fluorescence in situ hybridization (FISH)
specimen type and requirements
Peripheral blood: 5-6 mL in sodium heparin (green-top) tube.
Bone marrow: 2-3 mL in sodium heparin (green-top) tube.
Bodily fluids: Bodily fluids for diagnostic testing of hematological cancers (subject to specimen viability). Preferred transport in equal parts RPMI.
Lymphoid tissue: Transport in RPMI.
FFPE tissue: no decalcification (except for centromere as well as locus specific FISH probes).
Note: Use refrigerated cold pack for transport. Make sure cold pack is not in direct contact with specimen.
DO NOT FREEZE.
Probe Prioritization: If samples are insufficient to complete the whole FISH panel, Genoptix will contact client to prioritize testing,
Tech-only (TC): 3 days
Global (TC & PC): 5 days
medicare moldx cpt code
Laboratory developed test (LDT)
Global (TC & PC) or Tech-only (TC)