Hematologic Diseases

Available as a global test only. Markers tested by flow cytometry include CD3, CD5, CD19, CD20, CD22, CD43, CD79b, CD81.

disease state indication(s)
Chronic lymphocytic leukemia (CLL)

clinical use
The CLL MRD Profile by flow cytometry evaluates for the presence of minimal residual disease (MRD) in patients with previously diagnosed and treated chronic lymphocytic leukemia (CLL). The limit of detection is 0.01%.

methodology/product platform
Flow cytometry

specimen type and requirements
Peripheral blood: 5-6 mL in sodium heparin (green-top) tube. EDTA is also acceptable. Acid-citrate-dextrose (ACD) is unacceptable.
Bone marrow aspirate: ≥ 1mL with a minimum of 1 million cells. Do NOT fix. Preferred sample in sodium heparin (required if Cytogenetics is also performed), EDTA is acceptable. All others not acceptable.
Note: Use refrigerated cold pack for transport. Make sure cold pack is not in direct contact with specimen.
DO NOT FREEZE. Transport to lab ASAP.

turnaround time
Global (TC & PC): 24-48 hours

cpt code(s)
88184 (x1)
88185 (x7)
88187 (x1)

medicare moldx cpt code
Not applicable

regulatory classification
Laboratory developed test (LDT)

ordering option
Global (TC & PC)