Amplification of the ibroblast growth factor receptor 1 (FGFR1) gene is detected by fluorescence in situ hybridization (FISH).
disease state indication(s)
Non-Small Cell Lung Cancer (NSCLC)
Predictive FGFR1 overexpression has been identified as a driver event in non-small cell lung cancer (NSCLC), particularly squamous cell carcinoma. Targeted therapies are under investigation.
Fluorescence in situ hybridization (FISH)
specimen type and requirements
Preferred: One (1) or two (2) formalin-fixed, paraffin-embedded (FFPE) blocks containing tumor tissue from the most recent surgery or biopsy.
Acceptable Alternative: Two (2) to three (3) unstained FFPE tissue sections recently cut at 4 µm thickness on glass slides, plus accompanying H&E stained slide.
Unacceptable: Specimens preserved in alternative (non-formalin) fixatives, decalcified specimens, fresh or frozen tissue.
Note: Use refrigerated cold pack for transport. Make sure cold pack is not in direct contact with specimen.
DO NOT FREEZE.
Global (TC & PC): 7 days
medicare moldx cpt code
Laboratory developed test (LDT)
Global (TC & PC)