Hematologic Diseases

Chromosomal gains, losses, deletions, inversions, or translocations commonly associated with various hematological disorders and solid tumors are detected by fluorescence in situ hybridization (FISH).

disease state indication(s)
Various, case dependent

clinical use
Chromosomal gains, losses, deletions, inversions, or translocations commonly associated with various hematological disorders and solid tumors are detected by fluorescence in situ hybridization (FISH).

methodology/product platform
Fluorescence in situ hybridization (FISH)

specimen type and requirements
Peripheral blood: 5-6 mL in sodium heparin (green-top) tube.
Bone marrow: 2-3 mL in sodium heparin (green-top) tube.
Bodily fluids: Bodily fluids for diagnostic testing of hematological cancers (subject to specimen viability): Preferred transport in equal parts RPMI.
Lymphoid tissue: Transport in RPMI.
FFPE tissue: no decalcification.
Note: Use refrigerated cold pack for transport. Make sure cold pack is not in direct contact with specimen.
DO NOT FREEZE.

turnaround time
Tech-only (TC): 3 days
Global (TC & PC): 5 days

cpt code(s)
Computer assisted:
88367 (x1)
88373 (xN)
88374 (xN)
Manual:
88368 (x1)
88369 (xN)
88377 (xN)

medicare moldx cpt code
Not applicable

regulatory classification
Laboratory developed test (LDT)

ordering option
Global (TC & PC) or Tech-only (TC)