Hematologic Diseases

Detects mutations in key genes recurrently mutated in myeloproliferative neoplasms (MPN). DNA sequence of targeted regions of the CALR, CSF3R, JAK2, MPL and SETBP1 genes is determined using next generation sequencing technology.

disease state indication(s)
Myeloproliferative neoplasms (MPN), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), chronic neutrophilic leukemia (CNL), and atypical chronic myelogeneous leukemia (aCML)

clinical use
The MPN Molecular Profile is intended as an aid in the diagnosis and subclassification of BCR-ABL1-negative myeloproliferative neoplasms (MPN). The profile includes analysis of genes known to be commonly mutated in BCR-ABL1-negative MPN, including polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), chronic neutrophilic leukemia (CNL), and atypical chronic myelogeneous leukemia (aCML).

methodology/product platform
Amplicon-based, next-generation sequencing (NGS)

specimen type and requirements
Peripheral blood: 2-3 mL in EDTA (purple-top) tube.
Bone marrow: 2-3 mL in EDTA (purple-top) tube.
Note: Use refrigerated cold pack for transport. Make sure cold pack is not in direct contact with specimen.
DO NOT FREEZE.

turnaround time
Global (TC & PC): 10-12 days

cpt code(s)
81450 (x1)

medicare moldx cpt code
Not applicable

regulatory classification
Laboratory developed test (LDT)

ordering option
Global (TC & PC)